Rod-shaped chemotherapy drug nanoparticles bind more efficiently to receptors on
cancer cells than those that are spherical-shaped. (Credit: UC Santa Barbara)

HEALTH & MEDICINE – Posted by Melissa Van De Werfhorst-UC Santa Barbara on Thursday, February 28, 2013 12:12

Nanorods 10,000x better at targeting cancer

UC SANTA BARBARA (US) — Changing the shape of chemotherapy drug nanoparticles makes them up to 10,000 times more effective, new research shows.

By changing nanoparticles from spherical to rod-shaped, bioengineers made them better able to specifically target and deliver anti-cancer drugs to breast cancer cells.

The findings could have a significant impact on the effectiveness of anti-cancer therapies and reducing the side effects of chemotherapy, researchers say.

“Conventional anti-cancer drugs accumulate in the liver, lungs and spleen instead of the cancer cell site due to inefficient interactions with the cancer cell membrane,” says Samir Mitragotri , professor of chemical engineering and Director of the Center for BioEngineering at University of California, Santa Barbara.

“We have found our strategy greatly enhances the specificity of anti-cancer drugs to cancer cells.”

Read more: – Nanorods 10,000x better at targeting cancer.

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