Fabrication of 3D multilayer tissue prototypes via layer-by-layer photomasking
(credit: U. Gurkan et al./Advanced Materials)

Creating 3D brain tissues in a lab dish

December 3, 2012

Borrowing from microfabrication techniques used in the semiconductor industry, MIT and Harvard Medical School (HMS) engineers have developed a simple, inexpensive way to create three-dimensional brain tissues in a lab dish, using brain cells taken from the primary cortex of rats.

The new technique yields tissue constructs that closely mimic the cellular composition of those in the living brain, allowing scientists to study how neurons form 3D connections and to predict how cells from individual patients might respond to different drugs.

The work also paves the way for developing bioengineered implants to replace damaged tissue for organ systems, according to the researchers.

Read more: Creating 3D brain tissues in a lab dish | KurzweilAI.

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